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. 2018 Apr 9;50(4):10. doi: 10.1038/s12276-017-0023-8

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© The Author(s) 2018

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Fig. 2 — LPP-DG synapses. Lateral perforant path (LPP) axons from layer II (LII) lateral EC (LEC) synapse on distal dentate gyrus (DG) granule cell dendrites in the outer molecular layer (OML). Loss of LRRTM4 results in a reduction in spine density at LPP-DG synapses. MPP-DG synapses. Medial perforant path (MPP) synapses form between incoming LII medial EC (MEC) afferents and DG granule cell dendrites in the middle molecular layer (MML). At MPP-DG synapses, loss of FLRT3 or LRRTM3 results in a reduction in spine density. Loss of NGL-2, or its pre-synaptic binding partner, netrin-G2, results in an increase in the paired-pulse ratio (PPR) that corresponds to an attenuated paired-pulse depression (PPD)