Table 3.
Potential new epigenetic targets in neuroblastoma at early preclinical research studies
| Family/Class | Gene symbol | Prognostic value | Function | Ref. |
|---|---|---|---|---|
| HMT / PKMT | NSD1 | Low is worse | Cell proliferation | 134 |
| HMT / PKMT | WHSC1 | High is worse | n.d. | 135 |
| HMT / PKMT | EZH2 | High is worse | Cell differentiation and gene expression regulator | 136 |
| HMT / PRMT | PRMT5 | High is worse | Cell proliferation / survival | 137 |
| HDM / KDM1 | KDM1A | High is worse | Cell proliferation / invasion | 43, 44 |
| HDM / JHDM | JMJD1A | n.d. | Migration / invasion | 138 |
| HDM / JHDM | JARID1B | High is worse | Invasion / chemoresistance | 139 |
| HDAC / Class I | HDAC2 | n.d. | Increased proliferation / survival | 140 |
| HDAC / Class I | HDAC5 | n.d. | Block differentiation / induce proliferation | 141 |
| HDAC / Class II | HDAC6 | n.d. | Regulates cell survival | 142 |
| HDAC / Class III | SIRT2 | n.d. | Increased proliferation | 130 |
| HDAC / Class IV | HDAC11 | n.d. | Regulates cell survival | 143 |