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. 2018 Apr 27;50(4):47. doi: 10.1038/s12276-018-0073-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. If you remix, transform, or build upon this article or a part thereof, you must distribute your contributions under the same license as the original. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/.

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Fig. 1 — a Concentration-response curves (CRCs) of 5-HT-induced rat mesenteric arterial contractions in the absence and presence of MK801. b CRC of MK801-induced rat mesenteric arterial contractions in the presence of a physiological concentration (200 nM) of 5-HT. c CRC of (+) and (−) MK801-induced rat mesenteric arterial contractions in the presence of 200 nM of α-methyl 5-HT, a selective 5-HT_2AR agonist. d Membrane potential (E_m)-independent CRCs of 5-HT-induced rat mesenteric arterial contractions in the absence and presence of MK801 after pretreatment with 70 mM KCl and nifedipine (1 µM). e E_m-independent CRCs of 5-HT-induced rat mesenteric arterial contractions in the absence and presence of ketamine after pretreatment with 70 mM KCl and nifedipine (1 µM). f CRC of MK801-induced rat mesenteric arterial contractions in the absence and presence of high (70 mM) KCl. g CRCs of phenylephrine-induced rat aorta contractions in the absence and presence of MK801. N in parentheses indicates the number of animals examined. *p < 0.05; **p < 0.01; N.S. not significant