Fig. 4. Inhibition of Kv1.5 by ketamine.

a (upper) Representative Kv1.5 current tracings elicited by voltage steps shown in the figure inset in the absence and presence of ketamine (100, 300, and 1000 µM); lower, Representative Kv1.5 current tracings recorded with the pipette containing ketamine (1000 µM) in the absence and presence of bath ketamine (100, 300, and 1000 µM). b Kv1.5 current amplitudes at +50 mV are plotted against time. The period of application of various concentrations of ketamine is indicated as solid bars. c CRCs of ketamine-induced Kv1.5 inhibition. N in parentheses indicates the number of cells examined