Fig. 2. Functional and clinical significance of CMTM2 expression.

a Expression status of CMTM2 in gastric cancer (GC) cell lines, as detected by nested qRT-PCR. LNCap and PC3 prostate cancer cells were used as positive and negative controls, respectively. b Increased CMTM2 expression in CMTM2-induced MKN28 cells. c Reduced proliferation of CMTM2-overexpressing MKN28 cells. d Migration and invasion of CMTM2-induced and empty vector-induced MKN28 cells. Scale bar, 100 μm. e Kaplan-Meier survival curves compare the overall survival between the CMTM2-low group and the CMTM2-high group for intestinal-type GC (n = 269, left) and diffuse-type GC (n = 240, right) cohorts. NS, not significant. *P < 0.01