Fig. 6. ipo13 mRNA rescues the phenotypes in ipo13-deficient morphants.

a Lateral view of larvae injected with MO and/or rescue full-length mRNA. Larvae co-injected with MO and rescue mRNA display a relatively normal morphology that is similar to the morphology in the rescue mRNA only group on 3 dpf. Meanwhile, compared to the MO only group, the coloboma phenotype decreases significantly in the rescue group. b, c MO and mRNA co-injected larvae show dramatic recovery in both axial length (b) and eye area (c). Rescue experiments were repeated three times