Fig. 1. Factors modulating the critical period.

Factors that are known to control the critical period to date are depicted in the area where they operate predominantly. Factors with unclear action sites are listed on the left side and the neurodevelopmental disease-related factors are listed on the right side. The green cell is a PV (+) inhibitory neuron, the blue cell is a pyramidal neuron, and the orange cell is a glia cell (microglia). Perineuronal net is depicted in pale gray. Receptors or channels are red and cell adhesion molecules are black