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. 2018 Apr 13;50(4):21. doi: 10.1038/s12276-017-0002-0

Fig. 5. High and low Sirt3 expression modified by microbiome transfer have different effects on colon tumorigenesis.

Fig. 5

a Images of distal colons from SIRT3KO TP and WT TP mice after AOM/DSS tumorigenesis. b Comparison of polyp numbers between SIRT3KO TP and WT TP mice (n = 6). Data are represented as the mean ± SEM. P < 0.05; **P < 0.01; ***P < 0.001; by unpaired Student’s t test. c Western blots of intestinal SIRT3, GSK3β, β-catenin and Claudin15 expression from SIRT3KO TP and WT TP mice after AOM/DSS tumorigenesis. d Comparison of serum adiponectin levels between SIRT3KO TP and WT TP mice (n = 5–6). Data are represented as the mean ± SEM. P < 0.05; **P < 0.01; ***P < 0.001; by unpaired Student’s t test. e Comparison of phylum-level proportional abundance of SIRT3KO TP and WT TP mice (n = 5–6) by Pacbio sequencing. f Heat map of bacterial species from feces that had a difference in abundance between SIRT3KOTP and WTTP mice (n = 6) by Pacbio sequencing. Data were analyzed by the Mann–Whitney test. g PCoA of SIRT3KO TP and WT TP mice (n = 6) by Pacbio sequencing. PC1 and PC3 explain 60.5 and 10.30% of the variation, respectively. n no significance