Fig. 4. miR-125a-5p reduces pulmonary vascular remodeling in vivo.

Early miR-125a-5p agomir treatment significantly reduced pulmonary vascular remodeling. The images in A-F show representative H&E-stained sections of right lung tissue sections in the indicated groups; the scale bars represent 100 μm. a Control, b MCT-PAH, c the early therapy group with 1 nM miR-125a-5p agomir, d the early therapy group with 2 nM miR-125a-5p agomir, e the late therapy group with 1 nM miR-125a-5p agomir, and f the late therapy group with 2 nM miR-125a-5p agomir. g Summary of vascular wall area in the indicated groups (n = 5–6 rats per group). ****p < 0.0001 vs. control; ^##p < 0.01 and ^####p < 0.0001 vs. MCT-PAH; ^†p < 0.05 and ^††p < 0.01