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. 2018 Apr 27;50(4):45. doi: 10.1038/s12276-018-0068-3

Fig. 7. Reciprocal negative regulation between TGF-β1/IL-6 and miR-125a-5p in PASMCs.

Fig. 7

a Overexpressing miR-125a-5p inhibited the expression of TGF-β1, whereas downregulating miR-125a-5p upregulated the expression of TGF-β1. Stimulating cells with TGF-β1 upregulated the expression of miR-125a-5p beginning on day 2. b Overexpressing miR-125a-5p inhibited the expression of IL-6, whereas downregulating miR-125a-5p upregulated the expression of IL-6. Stimulating cells with IL-6 upregulated the expression of miR-125a-5p measured on day 2. AGO-NC and ANTA-NC refer to negative controls for the miR-125a-5p agomir and antagomir, respectively. D, Day. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001