Table 1.

Preparation of fallypride using tracer-level [¹⁹F]KF and the comparison with ¹⁸F-radiosynthesis

Entry	Base	Solvent	T (°C)	Time (min)	Yield (%)	18F RCY (%)a
1b	K2CO3 (0.8 mg)	ACN	100	30	n/a	n/a
2	K2CO3 (3.0 mg)	ACN	100	30	41	60
3	K2CO3 (0.8 mg)	ACN	100	30	63	74
4	TBAB (4.0 mg)	ACN	100	10	55	68 ± 1.6c
5	K2CO3 (0.8 mg)	ACN	100	10	64 ± 4d	77
6	KHCO3 (0.8 mg)	ACN	100	10	55	82
7	KHCO3 (1.6 mg)	ACN	100	10	63	79

^aRCY was determined by HPLC analysis of the crude product.

^bNo KF was used to test background reaction. Glass reaction vial was washed with K₂CO₃. Fallypride concentration of 85 ± 6 ng/mL was detected.

^cRCY obtained from Ref. 17

^dReaction was run in multiple times (n = 4) and found good reproducibility.