Table 1.
Particle Sizes (n = 150) and Surface Compositions As Measured by XPS (n = 5) and ToF-SIMS (n = 5) of Batch 1 ASD (Naproxen_PVPVA Spray Dried from Methanol and Acetone in Volumetric Ratio of 1:1) and Batch 2 ASD (Naproxen_PVPVA Spray Dried from Methanol and Acetone in Volumetric Ratio of 1:9)
| formulation | XPS (C 1s spectra) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| particle size (μm) | % surface composition (theoretical) | % surface composition (measured) | ToF-SIMS (% normalized counts) | ||||||
|
|
|
|
|
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| D10 | D50 | D90 | naproxen | PVPVA | naproxen | PVPVA | m/z 231 (naproxen) | m/z 112 (PVPVA) | |
| Batch 1 | 0.1 ± 0.0 | 0.5 ± 0.2 | 1.1 ± 0.1 | 54 | 46 | 12 ± 2 | 88 ± 2 | 0.008 ± 0.002 | 0.025 ± 0.002 |
| Batch 2 | 0.1 ± 0.1 | 0.5 ± 0.1 | 1.0 ± 0.1 | 54 | 46 | 9 ± 2a | 91 ± 2a | 0.003 ± 0.001b | 0.025 ± 0.001 |
a
*p < 0.05.
b
**p < 0.01, significantly different from Batch 1.