Table 3.

Multivariable regression models for association between long term glycemic control and cardiovascular autonomic neuropathy collected at the current SEARCH Cohort visit(2011-2015)

Dependent Variable: CAN Independent Variable: AUC A1c adjusted for time between measures	Type 1 diabetes		Type 2 diabetes
	OR (95%CI)	P-value	OR (95%CI)	P-value
Model 1 = AUC A1c	1.28 (1.11;1.48)	0.0006	1.07 (0.77;1.48)	0.69
Model 2 = Model 1+ age, sex	1.3 (1.13;1.5)	0.0002	1.07 (0.77;1.49)	0.68
Model 3 = Model 1+ BMI	1.29 (1.11;1.49)	0.0006	1.11 (0.79;1.56)	0.54
Model 4 = Model 1 + SBP, DBP	1.26 (1.09;1.47)	0.002	1 (0.71;1.41)	1.00
Model 5 = Model 1 + Trig	1.22 (1.05;1.43)	0.010	0.93 (0.65;1.33)	0.69
Model 6 = Model 1 + ACR	1.26 (1.07;1.47)	0.005	1.27 (0.86;1.88)	0.22
Model 7 = Model 1 + age, sex, BMI, SBP, DBP, Trig, ACR	1.24 (1.04;1.46)	0.01	1.08 (0.69;1.7)	0.72

CAN: cardiovascular autonomic neuropathy, OR: odds ratio, CI: confidence interval, BMI: body mass index, SPB and DBP: systolic and diastolic blood pressure, trig: triglycerides, ACR: albumin: creatinine ratio, AUC: area under the curve