Table 2.

Laboratory Values and MAS/HLH Criteria of 23 Adults with SLE and MAS

Maximum Laboratory Values during episode	Adults, n=23
Ferritin, ng/mL (normal 20–400)*	8,111 (5,670–22,070)
LDH, U/L (107–231) n = 13	671.5 (486–1,443)
AST, U/L (9–30)	161 (68–475)
ALT, U/L (10–50)	68 (38–228)
CRP, mg/L (0.0–3.0) n=15	60.5 (24.9–155.5)
ESR, mm/hr (0–18) n=14	72 (53–101)
Triglycerides, mg/dL (35–135)	239 (155–446)
Minimum labs during episode, mean (range)
WBC, K/uL (4–10)	2.02 (1.04–4.84)
Hematocrit, % (36–48)	20.2 (18.5–24.4)
Platelets, K/uL (150–450)	41 (21–122)
Classification Systems
Number of Ravelli clinical criteria†	2.3 (1.0)
Number of Ravelli laboratory criteria	3.7 (1.0)
Number of HLH-2004 criteria‡,§	4.1 (1.3)
Percentage who met HLH-2004 criteria	39.1
Percentage with bone marrow biopsy‖	43.5
Percentage of bone marrow biopsies with hemophagocytosis	60

^*All lab values are median with inter-quartile range

^†MAS by Ravelli criteria: ≥ 1 clinical and ≥ 1 laboratory criteria. Mean (standard deviation).

^‡SD = Standard deviation

^§HLH-2004 guidelines: ≥ 5 of 8 criteria.

^‖Percentages for bone marrow biopsy positivity are based upon those with bone marrow biopsy during hospitalization.