Table 3.

Summary statistics of association between expression levels of the genes (MTUS1 and C14orf79) and AD status as well as Braak Stage.

Source	Brain region	Predictor	MTUS1			C14orf79
			β	SE	P	β	SE	P
Eisai Bio Bank (RNA-Seq)	HIPP	AD Status	0.38	0.16	0.02	0.04	0.14	0.76
	HIPP	Braak Stages	0.16	0.04	3.9×10−4	−0.07	0.03	0.06
Mt. Sinai Hospital (Microarray)	CER	AD Status	0.00	0.02	0.78	−0.13	0.02	7.5×10−8
	DLPFC	AD Status	0.09	0.04	0.01	−0.13	0.02	3.3×10−7
	VCX	AD Status	0.09	0.03	0.01	−0.15	0.03	2.1×10−8

Brain regions tested were hippocampus (HIPP), cerebellum (CER), dorsolateral prefontal cortex (DLPFC), visual cortex (VCX). Positive effect (β) for AD status means that a gene is up-regulated in AD cases vs. in controls. Positive effect for Braak stages means that the expression of a gene is positively correlated with the Braak stages.