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. Author manuscript; available in PMC: 2018 May 7.
Published in final edited form as: Mol Psychiatry. 2017 Nov 7;23(5):1293–1302. doi: 10.1038/mp.2017.200

Table 1.

Summary of existing genomewide association studies of cannabis-related phenotypes

Author, Date Phenotype N Genomewide significant SNPs Gene-based significance Heritability
Agrawal, 2011; PMC3117436 DSM-IV cannabis dependent 708 cases, 2346 controls (exposed) none - -
Verweij, 2013; PMC3548058 Cannabis Use 10,091 none none 6% (p=.28)
Agrawal, 2014; PMC3943464 Factor score of DSM5 criteria 3,053 none C17orf58, BPTF and PPM1D 21% (p=.13)
Minica, 2015; PMC4561059 Cannabis use
Age at initiation		 6,774 none none 25% (p=.002)
Sherva, 2016; PMID27028160 Cannabis dependence symptom count 14,754 rs143244591 (chr3:149296148; RP11-206M11.7; p=4.3E-10); rs146091982 (chr10:93900201; SLC35G; p=1.3E-9)
rs77378271 (chr8:3215967; CSMD1;p=2.2E-8);		 - -
Stringer, 2016; PMID27023175 Cannabis use 32,330 + 5,627 none NCAM1, CADM2, SCOC and KCNT2. 13–20% (p<.001)