Table 3.
Association results for SNPs at p-value ≤ 1 × 10−6 in 2,080 cannabis dependent cases and 6,435 cannabis-exposed controls of European-American descent.
| SNP | Chr: position | Function | Effect Allele | Alternate Allele | Meta-analysis
|
Direction of effects** | ||
|---|---|---|---|---|---|---|---|---|
| Effect size (β) | SE | P-value | ||||||
| rs112825709 | 10:120622014 | intergenic | A* | C | 0.50 | 0.09 | 8.04E-08 | +++++ |
| rs151284751 | 10:120622746 | intergenic | A* | C | 0.50 | 0.09 | 8.06E-08 | +++++ |
| rs145575521 | 10:120622907 | intergenic | T | C | −0.51 | 0.09 | 4.39E-08 | − − − − − |
| rs79516280 | 10:120624808 | intergenic | A | G | −0.51 | 0.09 | 4.34E-08 | −−−−− |
| rs75312482 | 10:120626227 | intergenic | T* | C | 0.51 | 0.09 | 4.66E-08 | +++++ |
| rs1409568g | 10:120630785 | intergenic | T | C | −0.50 | 0.09 | 3.95E-08 | −−−−− |
| rs77300175 | 10:120633376 | intergenic | T* | C | 0.53 | 0.09 | 1.30E-08 | +++++ |
| rs7098706g | 10:120639977 | intergenic | T | C | −0.52 | 0.09 | 2.44E-08 | −−−−− |
| rs118006754 | 10:120641184 | intergenic | T* | G | 0.51 | 0.09 | 4.12E-08 | +++++ |
| rs7074123 | 10:120643763 | intergenic | A | C | −0.52 | 0.09 | 1.79E-08 | −−−−− |
| rs7920901 | 10:120648450 | intergenic | T* | C | 0.52 | 0.09 | 1.74E-08 | +++++ |
| rs57602752 | 10:120649972 | intergenic | A | C | −0.52 | 0.09 | 1.88E-08 | −−−−− |
| rs115048844 | 10:120651442 | intergenic | C* | G | 0.52 | 0.09 | 1.86E-08 | +++++ |
| rs1961317 | 10:120654022 | intergenic | T* | C | 0.52 | 0.09 | 2.08E-08 | +++++ |
| rs147702664 | 10:120658617 | intergenic | A | G | −0.57 | 0.10 | 4.07E-08 | −−−−− |
| rs149791363 | 10:120658646 | intergenic | A | C | −0.58 | 0.11 | 3.76E-08 | −−−−− |
| rs150525973 | 10:120659352 | intergenic | T* | C | 0.54 | 0.10 | 3.27E-08 | +++++ |
| rs79277226 | 10:120660716 | intergenic | A* | G | 0.49 | 0.09 | 5.23E-08 | +++++ |
| rs113036365 | 10:120663067 | intergenic | T* | G | 0.48 | 0.09 | 6.37E-08 | +++++ |
| rs60120125 | 10:120663137 | intergenic | T | C | −0.48 | 0.09 | 6.40E-08 | −−−−− |
| rs61538293 | 10:120663338 | intergenic | C | G | −0.49 | 0.09 | 7.34E-08 | −−−−− |
| rs111332403 | 10:120666212 | intergenic | A | G | −0.49 | 0.09 | 2.15E-08 | −−−−− |
| rs12771281 | 10:120675667 | intergenic | C | G | −0.41 | 0.08 | 7.11E-07 | −−−−− |
| rs12413263 | 10:120675738 | intergenic | A | C | −0.40 | 0.08 | 5.67E-07 | −−−−− |
| rs35728709 | 10:120706542 | intergenic | T* | C | 0.41 | 0.08 | 7.30E-07 | +++++ |
*
indicates that the effect allele is also the minor allele in individuals of European descent.
**
Order of effect sizes from studies is CATS, COGA-cc, COGA-fGWAS, OZALC+, and SAGE
g
SNP genotyped in at least one sample. All other SNPs were imputed across samples.