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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: J Allergy Clin Immunol. 2018 Feb 15;141(5):1711–1725.e9. doi: 10.1016/j.jaci.2018.02.003

Figure 6.

Figure 6

Anti-ST2 blocked development of oral food allergen-induced anaphylaxis. (A) Timeline for mating of females with FT−/− males or WT males, for antibody (Ab) treatment one hour before pup skin sensitization on PND3-13 with food and environmental allergens. FT+/− pups received an intraperitoneal injection of 8 8 μg anti-ST2 or IgG2b isotype control at 1 hr before skin sensitization #1, 12 μg antibody/g pup at 1 hr before skin sensitization #2 and #3, and then 15 μg antibody/g pup at 1 hr before skin sensitization #4. (B) Food allergen-induced temperature changes after oral gavage on postnatal day 15. (C) Anti-peanut specific IgE, IgG2b, IgG1 and monomeric IgA in serum from pups in panel B. (D) Serum Mcpt-1 was measured by ELISA. *, p<0.05 as compared to groups, 1, 3, 5 and 6.