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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: J Allergy Clin Immunol. 2018 Feb 15;141(5):1711–1725.e9. doi: 10.1016/j.jaci.2018.02.003

Figure 7.

Figure 7

Oral pre-exposure to PNE induced tolerance in FT+/− pups. (A) Timeline for induction of mating of females with FT−/− males or WT males, for pup pre-exposures on PND 3-6, and for pup skin treatments on PND6-18 with food and environmental allergens. Intestines were flushed with saline before RT-qPCR analysis (B) Food allergen-induced temperature changes after oral gavage on days 20. *, p<0.05 as compared to all other groups. For pups from panel B, shown is the RT-qPCR of (C) pup skin TSLP, (D) pup intestine TSLP, and (E) pup ileum IL-33. (F) Anti-peanut specific serum IgE, IgG2b, IgG1 and IgA from pups in panel 2 as determined by ELISA. TBS, Tris-buffered saline. *, p<0.05 as compared to groups 1, 2, and 4.