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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: J Allergy Clin Immunol. 2018 Feb 15;141(5):1711–1725.e9. doi: 10.1016/j.jaci.2018.02.003

Figure 8.

Figure 8

Oral pre-exposure to PNE to induce tolerance in FT+/− pups was less effective when their skin was pre-exposed to the ubiquitous environmental allergen Alt during oral pre-exposure to PNE. (A) Timeline for induction of OVA-induced lung inflammation in females, mating of females with FT−/− males, for pup pre-exposures on PND 3-6, for pup skin sensitization on PND6-18 with food and environmental allergens and for oral challenge on PND 20. (B) Food allergen-induced temperature changes after oral gavage on day 20. *, p<0.05 as compared to the group without the asterisk. (C) Anti-peanut specific serum IgE, IgG2b, IgG1 and monomeric IgA from pups in panel B as determined by ELISA. *, p<0.05 as compared to all groups without one asterisk. **, p<0.05 as compared to indicated group. N=8-10 pups/group.