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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Arthritis Care Res (Hoboken). 2018 Jul 12;70(8):1228–1237. doi: 10.1002/acr.23462

Table 3.

Criteria for treatment failure at 3 months (when a patient fails to improve on at least 4/6 of the criteria or over 50% of applicable criteria)

  1. Patient pain as measured by VAS

  2. Total number of clinically active lesions&

  3. Number of radiological lesions by WBMRI or bone scintigraphy

  4. Size and degree of marrow edema of CNO lesions and/or presence of soft tissue swelling/inflammation related to CNO lesion on imaging

  5. Physician VAS

  6. Abnormal ESR and/or CRP after exclusion of other potential causes*

VAS: visual analogue scale: CNO: chronic nonbacterial osteomyelitis; WBMRI: whole body magnetic resonance imaging; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein.

&

Clinically active lesion is defined as a body part with focal tenderness, and/or swelling, and/or warmth in addition to patient’s report of pain at a known CNO lesion site.

*

Abnormal ESR is defined as ≥20 mm/hr and abnormal CRP is defined as ≥1 mg/dL.