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. Author manuscript; available in PMC: 2018 Sep 21.
Published in final edited form as: Mol Psychiatry. 2017 Nov 7;23(7):1606–1613. doi: 10.1038/mp.2017.216

Figure 1.

Figure 1

A. Differential network structure and disruptions in layer 3 PV cell (left) and PC (right) networks. The mean degree of connectivity of the DEGs (x’s) were compared to randomly generated networks (ovals) across cell types and diagnoses (unaffected comparison-C and schizophrenia-SZ). Any network plotted above the whiskers in the box plots is significantly connected (p<0.001). B. WGCNA from L3 PV cells and PCs. Genome-wide coexpression modules are detected in L3 PV cells (top) and L3 PCs (bottom). Coexpression modules in each cell-type are identified by a randomly assigned color and the same color in different cell types does not represent the same coexpression module. Modules that are significantly enriched for DEGs are bolded and those that are enriched for mitochondrial transcripts are shaded gray. The PV red and PC turquoise modules have significant overlap in gene expression, suggesting a shared regulatory network structure across cell types.