Table 3.
Top differentially-expressed genes in PV cells with > 40% decrease (q<0.05) in expression in schizophrenia subjects relative to unaffected comparison subjects.
| Gene Symbol | Gene Name | % decrease |
|---|---|---|
| ANAPC13 | anaphase promoting complex subunit 13 | 58.4 |
| TOLLIP | toll interacting protein | 57.7 |
| NDUFA13 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 | 54.8 |
| PITPNB | phosphatidylinositol transfer protein, beta | 52.4 |
| EFTUD2 | elongation factor Tu GTP binding domain containing 2 | 51.8 |
| FEZ1* | fasciculation and elongation protein zeta 1 (zygin I) | 50.9 |
| WDR41 | WD repeat domain 41 | 49.8 |
| RAC1* | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 49.4 |
| NBR1 | neighbor of BRCA1 gene 1 | 48.9 |
| RIOK1 | RIO kinase 1 | 48.4 |
| PPT1* | palmitoyl-protein thioesterase 1 | 47.8 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 47.5 |
| RGS4* | regulator of G-protein signaling 4 | 47.3 |
| UQCRC1 | ubiquinol-cytochrome c reductase core protein I | 46.5 |
| ATP6V1G1 | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 | 46.4 |
| RTN4* | reticulon 4 | 46.1 |
| TRIM37 | tripartite motif containing 37 | 45.7 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 45.7 |
| EIF5 | eukaryotic translation initiation factor 5 | 45.5 |
| ESRRG | estrogen-related receptor gamma | 45.3 |
| APBB1IP | amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein | 45.3 |
| SRPRB | signal recognition particle receptor, B subunit | 45.2 |
| NTM | neurotrimin-like /// neurotrimin | 45.1 |
| FAM174A | family with sequence similarity 174, member A | 44.6 |
| SLC4A1AP | solute carrier family 4 (anion exchanger), member 1, adaptor protein | 44.4 |
| CLCN4 | chloride channel, voltage-sensitive 4 | 44.2 |
| FAT1* | FAT atypical cadherin 1 | 43.6 |
| SUSD1 | sushi domain containing 1 | 43.6 |
| IDH3B | isocitrate dehydrogenase 3 (NAD+) beta | 43.5 |
| GRIP1* | glutamate receptor interacting protein 1 | 43.1 |
| PPP3CB* | protein phosphatase 3, catalytic subunit, beta isozyme | 43.1 |
| RAB11A | RAB11A, member RAS oncogene family | 42.9 |
| NACA | nascent polypeptide-associated complex alpha subunit | 42.7 |
| RHOQ | ras homolog family member Q | 42.4 |
| MRPL33 | mitochondrial ribosomal protein L33 | 41.8 |
| RAD21 | RAD21 homolog (S. pombe) | 41.0 |
| NDUFS2 | NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) | 40.4 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 40.1 |
*
Denotes gene previously implicated with schizophrenia