Table 4.
Comparison of altered gene pathways in DLPFC layer 3 PV cells and PCs in schizophrenia.
| PV cell analysis | PC analysis | |||||
|---|---|---|---|---|---|---|
| Pathway | DEGs in pathway* | p-value | % DEGs decreased | DEGs in pathway* | p-value | % DEGs decreased |
| Oxidative Phosphorylation | 22 (24.2%) | < 10−5 | 90.9% | 61 (67%) | < 10−34 | 100% |
| Mitochondrial Dysfunction | 27 (19.1%) | < 10−4 | 88.9% | 73 (51.8%) | < 10−30 | 100% |
| Tight Junction Signaling | 21 (20%) | < 10−3 | 57.1 % | 16 (14.8%) | 0.21 | 81.3% |
| Protein Ubiquitination Pathway | 20 (9.9%) | 0.26 | 55% | 55 (24.4%) | < 10−7 | 92.7% |
| EIF2 Signaling | 10 (6.2%) | 1 | 60% | 41 (24.4%) | < 10−5 | 90.2% |
| Clathrin-mediated Endocytosis Signaling | 20 (15.5%) | 0.006 | 55% | 31 (25%) | < 10−4 | 87.1% |
| Superpathway of Cholesterol Biosynthesis | 2 (9.1%) | 0.57 | 100% | 10 (43.5%) | < 10−3 | 100% |
| Regulation of Actin-based Motility by Rho | 14 (21.9%) | < 10−3 | 78.6% | 16 (28.6%) | < 10−3 | 87.5% |
| Pyrimidine Deoxyribonucleotides De Novo Biosynthesis I | 0 (0%) | 1 | 0% | 7 (46.7%) | < 10−3 | 85.7% |
*
Number and % of differentially expressed genes (DEGs) in each pathway. Bolded values represent pathways significant at a 5% FDR.