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. 2018 Apr;7(2):176–187. doi: 10.21037/tp.2018.04.01

Table 2. Proteins identified in the secretome of neonatal cardiac progenitor cells and the respective pathways involved.

Canonical pathways Proteins
Protein Ubiquitination Pathway HSPD1, PSMA3, HSPE1, UBE2D2, PSMD4, PSMA7, PSMD9, HSPA8, PSMB7, SKP1, TCEB1, PSMB3, PSMA1, HSP90AA1, PSMA5, USP14, PSMC3, UBE2N, PSME1, USO1, HSPA9, HLA-A, PSMB4, UBE2I, UCHL3, SUGT1, HLA-B, HSPH1, HSP90AB1
mTOR Signaling EIF3G, RPS10, EIF4A2, EIF3B, RPS5, RPS20, PPP2R1A, EIF4A1, EIF4EBP1, VEGFC, EIF3J, EIF4G1, PPP2CA, EIF3A, RPS7, RPS2, PDGFC, RPS3, RPS12, RPSA, RPS16, MAPK1, EIF3K, RPS4X, EIF3C, EIF3F
ERK/MAPK Signaling TLN1, CRKL, PPP1R12A, ITGA2, PPP1R7, PPP1CA, PXN, YWHAH, MAPK1, PPP2R1A, CRK, EIF4EBP1, PPP2CA
HIF-1α Signaling MMP3, MMP9, TCEB1, MAPK1, MMP10, HSP90AA1, APEX1, VEGFC, PDGFC
PI3K/AKT Signaling GDF15, ITGA2, PPP2R1A, MAPK1, HSP90AB1, HSP90AA1, YWHAH, EIF4EBP1, PPP2CA
HIPPO Signaling PPP1R12A, PPP1R7, PPP1CA, SKP1, PPP2R1A, YAP1, YWHAH, PPP2CA
VEGF Signaling EIF2S1, EIF2S2, ACTG1, PXN, MAPK1, EIF1, VEGFC, PDGFC
Neuregulin Signaling CRKL, ITGA2, MAPK1, CRK, HSP90AB1, HSP90AA1
Telomerase Signaling PTGES3, PPP2R1A, MAPK1, HSP90AB1, HSP90AA1, PPP2CA
Antiproliferative Role of TOB in T Cell Signaling TGFB1, SKP1, PABPC1, MAPK1