Table 3.
Area Under Curve, Sensitivity, Specificity, Positive Predictive Value, Negative Predictive Value for MELD, MELD-Na, CTP and ICG-PDR for Predicting Development of Liver Failure.
| Parameter (cut-off) | AUROC | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | LR+ | LR− |
|---|---|---|---|---|---|---|---|
| (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | |||
| MELD (>8.6) | .73 | 64.7 | 69.0 | 45.8 | 82.8 | 2.09 (1.18–3.70) | 0.51 (0.26–1.0) |
| (.59–.86) | (38.3–85.8) | (52.9–82.4) | (25.5–67.2) | (66.3–93.4) | |||
| MELD-Na (>12.9) | .62 | 58.8 | 57.1 | 35.7 | 77.4 | 1.37 (0.81–2.33) | 0.72 (0.39–1.35) |
| (.47–.77) | (32.9–81.5) | (40.9–72.3) | (18.6–55.9) | (58.9–90.4) | |||
| CTP (>6) | .80 | 82.3 | 73.8 | 56.0 | 91.1 | 3.14 (1.81–5.47) | 0.24 (0.08–0.68) |
| (.68–.92) | (56.6–96.2) | (57.9–86.1) | (34.9–75.6) | (76.3–98.1) | |||
| ICG-PDR (<9.25%/min) | .72 | 64.7 | 61.9 | 40.7 | 81.2 | 1.70 (1.01–2.86) | 0.57 (0.29–1.13) |
| (.57–.86) | (38.3–85.8) | (45.6–76.4) | (22.4–61.2) | (63.6–92.8) | |||
Abbreviations: MELD, Model for End Stage Liver Disease; MELD-Na, Model for End Stage Liver Disease-Sodium; CTP, Child-Turcotte-Pugh; ICG-PDR, Indocyanine Green-Plasma Disappearance rate.