Table 2.
Parameter estimates and their % relative standard errors (%RSE) obtained from model fittings for the static active caspase-3 and cell proliferation time-course data.
| Parameter | Definition | Value | Relative standard error (% RSE) |
|---|---|---|---|
| Static active caspase-3 parameters | |||
| Ktr (h-1) | Transit rate constant for transduction of active caspase-3 signal | 0.224 | 14 |
| SPAC (L/nmol) | Slope parameter affecting increase in active caspase-3 due to paclitaxel before 24 hours | 0.0125 | 29 |
| SPDE (L/nmol) | Hybrid slope parameter affecting increase in active caspase-3 due to paclitaxel, dasatinib, and everolimus after 24 hours | 0.0632 | 9 |
| Static cellular response parameters | |||
| kg (h-1) | First-order growth rate constant for JIMT-1 cells | 0.0088 | 6 |
| kd | Death rate constant due to increase in caspase-3 activity | 0.0421 | 4 |