Table 3.
Parameter estimates and their % relative standard errors (%RSE) obtained from model fittings of the PK/PD data from the novel 3DD cell culture system.
| Parameter | Definition | Value | Relative standard error (% RSE) |
|---|---|---|---|
| Paclitaxel PK parameters | |||
| CL (L/h) | Clearance of paclitaxel from the central compartment | 0.541 | 3 |
| Q (L/h) | Inter-compartment clearance of paclitaxel | 0.998 | 19 |
| Vp (L) | Volume of central compartment | 9.8 | 13 |
| Vt (L) | Volume of peripheral compartment | 25 | 23 |
| Dynamic active caspase-3 parameters | |||
| Ktr (h-1) | Transit rate constant for transduction of active caspase-3 signal | 0.146 | 3 |
| SPAC (L/nmol) | Slope parameter affecting increase in active caspase-3 due to paclitaxel | 0.312 | 6 |
| SDE (L/nmol) | Hybrid slope parameter affecting increase in active caspase-3 due to dasatinib and everolimus | 0.306 | 6 |
| Dynamic cellular response parameters | |||
| 0 (h-1) | Rate constant describing the exponential growth of cells | 0.0077 | 5 |
| 1 (h-1) | Rate constant describing the linear growth of cells | 7.3 | 62 |
| kd (h-1) | Cell death rate parameter due to increase in caspase-3 activity | 0.0096 | 3 |
| Ψ | Factor that allows for the switch from exponential to linear growth as tumor cell number increases | 20 (fixed) | – |