Figure 3.

Parallel Evolution

Table shows driver gene events with >10 subclonal mutations across the cohort. These genes were tested for evidence of parallel evolution using a permutation model accounting for overall gene mutation frequency and the number of biopsies per tumor (see STAR Methods). BAP1, SETD2, and PTEN were found to show significant evidence of parallel evolution (p < 0.05, FDR < 0.1). Example driver trees and accompanying tumor sampling images are presented for each significant gene: BAP1, PTEN, and SETD2. Parallel events are marked on the driver trees and clone color is matched from the tree to the corresponding sampled tumor region.

See also Data S3.