Figure 1.

Hypothetical models of the influence of LC on the activity of the saliency network (SAN), frontoparietal task network (FPN), and default model network (DMN). Box position with respect to the dashed line represents changes in activity level from a resting to task state, and arrows indicate the location of LC action in response to a task challenge. (A) LC increases activity of the SAN and FPN and suppresses activity of the DMN; (B) LC increases activity of the SAN, which in turn increases activity of the FPN and suppresses activity of the DMN.