Table 3.

SLC4 family of anion transporters.

SLC4	Expression	Function	Human disease	KO mouse	Pharmacology	References
SLC4A1 (AE1)	Erythrocytes, kidney, heart, colon	Cl−/${\text{HCO}}_3^{-}$ exchanger	Hemolytic anemia, distal renal tubular acidosis		Inhibitor: DIDS	Bruce et al., 1997; Jarolim et al., 1998; Karet et al., 1998; Shayakul and Alper, 2004; Stehberger et al., 2007; Romero et al., 2013
SLC4A2 (AE2)	Most epithelial cells	Cl−/${\text{HCO}}_3^{-}$ exchanger	Osteopetrosis		Inhibitor: DIDS	Gawenis et al., 2004; Romero et al., 2013
SLC4A3 (AE3)	Brain, kidney, GI tract, smooth muscle and heart	Cl−/${\text{HCO}}_3^{-}$ exchanger	Epilepsy, blindness	Lower seizure threshold	Inhibitor: DIDS	Sander et al., 2002; Hentschke et al., 2006; Romero et al., 2013; Ruffin et al., 2014
SLC4A8 (NDCBE)	Brain, kidney, testes and ovary	Na+–dependent Cl−/${\text{HCO}}_3^{-}$ exchanger, acid extruder	?		Inhibitor: DIDS	Chen et al., 2008; Burette et al., 2012
SLC4A10 (NCBE)	Brain	pH regulation (acid extrusion)	?	Higher seizure threshold, volume reduction of brain ventricles	Inhibitor: DIDS	Chen et al., 2008; Jacobs et al., 2008; Liu et al., 2011; Romero et al., 2013