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. 2018 May 1;8:127. doi: 10.3389/fcimb.2018.00127

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Copyright © 2018 Chen, Fan, Li, Zheng, Zhang, Yang, Liu, Liu and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunogenicity and protective efficiency of the NS1 R38A/K41A virus. Sera of WT or NS1 R38A/K41A virus infected mice (n = 6) was collected at 3, 7, and 14 d p.i. The neutralization titers (A) against the WT WSN, A/Puerto Rico/8/1934 (PR8), or A/California/04/2009 (CA04) viruses were determined by MN assays. Mice (n = 6) pre-inoculated with PBS or NS1 R38A/K41A virus in the previous experiments were infected with 10^3.88 PFU of WT WSN virus at 17 d p.i. Body weights (B) were examined for another 14 days and calculated as the percentage of the original body weight. The data present are the mean body weights. The survival rate (C) of mice (n = 6) pre-inoculated with PBS or the NS1 R38A/K41A virus against the WT WSN virus was calculated. All data from three independent experiments were analyzed. Data are shown as means with SD.