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. 2018 May 1;9:412. doi: 10.3389/fphar.2018.00412

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Copyright © 2018 Zhang, Terrando, Xu, Bang, Jordt, Maixner, Serhan and Ji.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Perioperative treatment of RvD1 and MaR1 attenuates fPOP. Impact of perioperative treatment of RvD1 and MaR1 (500 ng, 100 μl, i.v.), given 10 min and 24 h after bone fracture surgery (indicated by blue arrows), on mechanical allodynia, assessed by paw withdrawal threshold (A) and paw withdrawal frequency (B) in the von Frey test, as well as on cold allodynia, assessed by cold response scoring in the acetone test (C). ^∗P < 0.05 vs. vehicle (5% ethanol), two-way ANOVA followed by Bonferroni test, n = 5 mice/group. Data are presented as mean ± SEM.