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. 2018 May 1;9:412. doi: 10.3389/fphar.2018.00412

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Copyright © 2018 Zhang, Terrando, Xu, Bang, Jordt, Maixner, Serhan and Ji.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distinct actions of post-treatment of DHAand DHA-derived SPMs on fPOP. Impact of post-surgical treatment with DHA (500 μg, i.t.) or DHA-derived SPMs RvD1, MaR1, NPD1, and RvD5 (500 ng, 10 μl, i.t.), given 2 weeks after bone fracture surgery (indicated by blue arrows) on mechanical allodynia, assessed by measurements of paw withdrawal threshold (A) and paw withdrawal frequency (B) in the von Frey test, as well as of cold allodynia, assessed by cold response scoring in the acetone test (C). Note that post-treatment of DHA has no effects on fPOP. ^∗P < 0.05 vs. vehicle (10% ethanol), two-way ANOVA followed by Bonferroni test, n = 5–7 mice/group. Data are presented as mean ± SEM.