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. 2018 May 1;9:412. doi: 10.3389/fphar.2018.00412

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Copyright © 2018 Zhang, Terrando, Xu, Bang, Jordt, Maixner, Serhan and Ji.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Area under curve (AUC) comparison of distinct post-treatment effects of DHA and DHA-derived SPMs on fPOP. (A–C) AUC showing the effects of post-surgical IT treatment of DHA (500 μg, 10 μl) and NPD1, MaR1, RvD1, RvD3, RvD4, and RvD5 (500 ng, 10 μl), given 2 weeks after bone fracture surgery on mechanical and cold allodynia. AUC data were collected at 1–5 h after the drug injection. ^∗P < 0.05 vs. vehicle (10% ethanol), two-way ANOVA followed by Bonferroni test, n = 5–7 mice/group. Data are presented as mean ± SEM.