Table 1.

Epstein–Barr virus (EBV) and high-risk human papillomaviruses (HPVs) onco-proteins interactions can occur via β-catenin, JAK/STAT/SRC, PI3k/Akt/mTOR, and/or RAS/MEK/ERK signaling pathways and probably other paths.

The most common pathways of EBV and high-risk HPVs
HR-HPV Onco-proteins	E5→EGFR→RAS→RAF→MEK→ERK1/ERK2
	→AKT→mTOR
	→JAK→STAT→SRC
	→β-catenin
	E6→p53→AKT→mTOR
	E7→pRb→AKT→mTOR
EBV Onco-proteins	LMP1→JAK→STAT→SRC
	→β-catenin
	→PI3K→AKT→mTOR
	LMP2A→RAS→RAF→MEK→ERK1/ERK2
	→AKT→mTOR
	EBNA1→STAT→SRC
	→β-catenin