Figure 6.

Results of multiple-lesion symptom mapping (the SVR-MLSM model with volume control by voxelwise normalization, Model 17 in Table 3). Voxelwise associations between the presence of a lesion (AIL or WMH) and global cognition at baseline and 1 year after stroke were determined using SVR-MLSM. This multivariate approach assesses inter-voxel and inter-lesion correlations and identifies the voxels of AIL or WMH which have an independent contribution to the outcome. The significant clusters of AIL (in red) and WMH (in green) were shown with p < 0.05 from statistical inference based on 1,000 permutations.