Table 4.
SVR-MLSM results of white matter hyperintensities.
| Region | Patients with lesion (n)∧ | Region size in voxel (n) | Tested voxels (n) | Significant voxels of WMH [n (%)] | |
|---|---|---|---|---|---|
| Baseline MoCA | Year 1 MoCA | ||||
| Body of corpus callosum | 45 | 17,849 | 4,621 | 83 (1.80) | 0 |
| Splenium of corpus callosum* | 36 | 19,535 | 4,610 | 329 (7.14) | 363 (7.87) |
| Anterior corona radiata L* | 29 | 7,507 | 3,428 | 154 (4.49) | 192 (5.60) |
| Superior corona radiata L | 40 | 8,929 | 6,886 | 34 (0.49) | 0 |
| Superior corona radiata R | 52 | 8,759 | 6,062 | 219 (3.61) | 40 (0.66) |
| Posterior corona radiata L* | 35 | 5,325 | 3,766 | 157 (4.17) | 324 (8.60) |
| Posterior corona radiata R* | 49 | 5,953 | 4,670 | 152 (3.25) | 383 (8.20) |
| Posterior thalamic radiation L* | 27 | 6,387 | 3,391 | 149 (4.39) | 347 (10.23) |
| Posterior thalamic radiation R | 32 | 5,400 | 3,335 | 398 (11.93) | 142 (4.26) |
| Sagittal stratum L* | 12 | 2,184 | 280 | 76 (27.14) | 99 (35.36) |
| Sagittal stratum R | 14 | 2,173 | 415 | 164 (39.52) | 99 (23.86) |
| Superior longitudinal fasciculus L | 14 | 9,386 | 2,045 | 64 (3.13) | 0 |
| Superior longitudinal fasciculus R* | 11 | 9,580 | 2,737 | 0 | 55 (2.01) |
| Tapetum R | 36 | 663 | 613 | 36 (5.87) | 0 |
Regions where there were significant WMH clusters (p < 0.05) for global cognition at baseline and 1 year after stroke. The remaining regions in ICBM-DTI-81 white matter tract atlas contained no significant voxels either for baseline or 1 year cognitive impairment; these regions are not shown here. L, left; R, right.
∧
Number among 76 included patients had WMH that overlapped (≥1 voxel) with the specified region of interest in ICBM-DTI-81 atlas.
*
Regions where more WMH clusters were significantly associated with the long-term cognitive impairment than short-term cognitive impairment.