Table 1.
Medical history, laboratory investigations and oocyte collection outcomes for patients presenting with OMD
| Origin | Age (years) | Number of oocytes collected | FSH U/L | LH U/L | TSH U/L | Prolactin μg/L | Menst. | Comments | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GV | MI | MII | At. | Tot. | |||||||||
| Patients with PATL2 mutation | |||||||||||||
| P1 | Tunisia | 35 | 4 | 0 | 0 | 1 | 5 | 1.36 | |||||
| 34 | 2 | Medical records not available | |||||||||||
| 34 | 8 | Medical records not available | |||||||||||
| P2 | Tunisia | 28 | 9 | 0 | 0 | 11 | 20 | YES | |||||
| 28.9 | 15 | 0 | 0 | 4 | 19 | ||||||||
| P3 | Tunisia | 24 | 11 | 0 | 0 | 5 | 16 | 10.31 | 3.54 | 22.28 | 1 GV maturated to M1 in vitro | ||
| P4 | Tunisia | 34.28 | 8 | 0 | 0 | 2 | 10 | 1.07 | 23 | YES | |||
| P5 | Arab | 41 | 2 | 0 | 0 | 2 | 4 | 9.39 | 6.1 | 2.3 | 12.9 | YES | |
| 42 | 3 | 1 | 0 | 1 | 5 | ||||||||
| P6 | Mauritania | 36 | 2 | 10 | 0 | 4 | 16 | 3.01 | 3.38 | 2.88 | 25 | YES | Cytoplasmic vacuoles in MI oocyte |
| 36.8 | 0 | 0 | 0 | 5 | 5 | ||||||||
| Patients without PATL2 mutation | |||||||||||||
| P7 | Algeria | 37 | 2 | 0 | 0 | 2 | 4 | 10.1 | 9.15 | 2.3 | YES | ||
| P8 | Algeria | 32 | 0 | 4 | 0 | 0 | 4 | ||||||
| 32 | 0 | 2 | 0 | 0 | 2 | ||||||||
| P9 | Tunisia | 32 | 0 | 0 | 0 | 8 | 8 | 3.73 | First cousin couple | ||||
| P10 | Tunisia | 37 | 0 | 2 | 0 | 3 | 5 | ||||||
| 37 | 2 | 3 | 0 | 3 | 8 | ||||||||
| P11 | Tunisia | 38.9 | 0 | 3 | 2 | 2 | 7 | 8.49 | 3.42 | 1.17 | 17.05 | ||
| P12 | Libya | 28 | 2 | 15 | 0 | 0 | 17 | 1.8 | 9.6 | ||||
| P13 | Arab | 33 | 0 | 3 | 2 | 7 | 12 | ||||||
| 37 | 3 | 1 | 0 | 11 | 15 | ||||||||
| P14 | Tunisia | 26 | 0 | 0 | 0 | 7 | 7 | YES | |||||
| P15 | Arab | 38 | 0 | 0 | 0 | 4 | 4 | ||||||
| 39 | 0 | 0 | 0 | 5 | 5 | ||||||||
| P16 | Arab | 33 | 0 | 5 | 2 | 2 | 9 | 4.65 | 2.71 | 14.25 | Heterozygous mutation in TUBB8 | ||
| P17 | Arab | 34 | 0 | 0 | 0 | 0 | 0 | YES | |||||
| P18 | Arab‐FR | 27 | 0 | 8 | 0 | 4 | 12 | ||||||
| P19 | Arab‐FR | 24 | 0 | 3 | 0 | 0 | 3 | ||||||
| P20 | 29 | 0 | 0 | 0 | 7 | 7 | |||||||
| P21 | Tunisia | 29 | 0 | 0 | 0 | 13 | 13 | YES | |||||
| P22 | Tunisia | 39 | 0 | 10 | 0 | 0 | 10 | ||||||
| P23 | Tunisia‐FR | No data available | No fertilisation | ||||||||||
| Mean P1‐P23 | 33.42 | 2.17 | 2.50 | 0.21 | 3.90 | 8.45 | |||||||
| Mean P1‐P6 | 34.00 | 6.00 | 1.38 | 0 | 3.89 | 10.00 | |||||||
| Mean P7‐P23 | 33.1 | 0.45 | 2.95 | 0.3 | 3.9 | 7.6 | |||||||
| Control cohort values (n = 238) | 34.4 | 2.2 | 1.8 | 6 | 2.3 | 9.1 | < 10.2 | < 16.9 | 0.5–5 | 2–20 | |||
Normal values correspond to couples where the male suffers from azoospermia or teratozoospermia (n = 234). Arab‐FR = French of Arab origin, At. = atretic, Tot. = total, Menst. = menstruation.