Fig. 2. Infertility and follicle atresia in Ck2β^fl/fl;GCre⁺ mice.

a Comparison of the accumulative number of pups per Ck2β^fl/fl female and Ck2β^fl/fl;GCre⁺ female for 6 months. At least five mice of each genotype were used in this assay. b Ovary weight to body weight ratio of Ck2β^fl/fl and Ck2β^fl/fl;GCre⁺ mice at 3, 4, 6, and 8 weeks of age after birth. For each time point, at least three mice of each genotype were used for analysis. Data are presented as the mean ± SEM. P < 0.05(*), 0.01(**) or 0.001(***). c–j Representative ovarian histology of Ck2β^fl/fl and Ck2β^fl/fl;GCre⁺ mice of 3, 4, 6, and 8 weeks of age, respectively. Images c’–j’ correspond to the partial magnification of images c–j. Yellow arrowheads in f’, h’, and j’ indicate atretic follicles. For each time point, at least three mice of each genotype were used for analysis. Scale bar: 100 μm