Fig. 7. MiR-17 family members participated in Dicer1 KD-induced senescence.

a The expression of miR-17 family of Dicer1-KD MSC (shRNA), negative MSC and control-MSC were detected by Real-time PCR. Decreased expressions of miR-93 and miR-20a was also appeared in MM-MSCs when compared with HC-MSCs. b Relative mRNA expression levels of p21 and p53 in Dicer1-KD MSC. c Decreased expressions of miR-93 and miR-20a was also appeared in MM-MSCs (n = 36) when compared with HC-MSCs (n = 18). d MM-MSCs were transfected with miR-93 and miR-20a harboring lentiviruses, and p21 levels after 48 h transfection was also detected. These experiments were performed three times. Compared with controls, the significance was set as *p ≤ 0.05; **p ≤ 0.01