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. 2018 May 3;9(5):515. doi: 10.1038/s41419-018-0552-7

Fig. 6. AMPK/MFF/Drp1 pathway participates in the damage of MDS-MSCs with iron overload.

Fig. 6

a The apoptotic rates of MSCs from health controls and MDS patients with or without iron overload. b The percentage of apoptotic MDS-MSCs with iron overload before and after adding DFO, NAC or Catalase. c Cell viability of MDS-MSCs with iron overload before and after adding DFO, NAC. d Cell viability of MDS-MSCs with iron overload before and after adding Catalase. e Representative confocal images of the mitochondrial morphology of MSCs from health controls and MDS patients. Mitochondria were visualized using an antibody to TOM20. Scale bars, 0.5 μm. f Protein expression of AMPKα, p-AMPKα-thr172, p-ACC-ser79, LC3, Beclin-1, ATG5 and ATG7 in MDS-MSCs with iron overload before and after treatment with DFO, NAC or Catalase. The results were presented as mean ± SD from at least three independent experiments