Skip to main content
. Author manuscript; available in PMC: 2018 May 8.
Published in final edited form as: J Am Chem Soc. 2017 Jul 13;139(29):9815–9818. doi: 10.1021/jacs.7b05448

Figure 4.

Figure 4

(Left) U23 deactivated ribozyme, treated with t4M to restructure stems with oligo-U domains (red) as t4M binding sites. (Right) Cleavage of U23 (blue dashed line) upon treatment with 10 μM t4M (■) or t4MMe (□) and RNA only (○) at 10 mM Mg2+ with 500 nM ribozyme, 10 μM t4M in 1X Tris-Cl buffer (pH = 7.6) at 37°C.