TABLE 2.
Multivariate linear regression analysis of predictors associated with interindividual variability of UGT2B17 protein abundance and UGT2B17-mediated testosterone and DHT-glucuronide formation
Statistically significant correlations are shown in bold.
| Dependent Variable | Independent Variable | Effect Size β (Coefficient) | S.E. | t-Stat | P Value |
|---|---|---|---|---|---|
| Protein abundance (pmol/mg of microsomal protein) | Intercept | −1.0 | 0.28 | −3.5 | 5.8 × 10−4 |
| Male | 0.84 | 0.18 | 4.5 | 9.7 × 10−6 | |
| Adolescence | 0.48 | 0.38 | 1.3 | 0.21 | |
| Adulthood | 1.67 | 0.25 | 4.7 | 4.2 × 10−6 | |
| Diplotype H3/H4 | 0.95 | 0.25 | 3.8 | 1.8 × 10−4 | |
| Diplotype H2/H2 | 1.1 | 0.23 | 4.7 | 4.2 × 10−6 | |
| Copy no.: 2 | 0.22 | 0.22 | 1.1 | 0.31 | |
| Testosterone -glucuronide formation (pmol/min per mg of microsomal protein) | Intercept | −13.9 | 7.0 | −2.0 | <0.05 |
| Male | 11.7 | 4.0 | 2.9 | 0.004 | |
| Adolescence | 15.2 | 8.8 | 1.7 | 0.09 | |
| Adulthood | 21.0 | 6.2 | 3.4 | 9.8 × 10−4 | |
| Diplotype H3/H4 | 12.7 | 5.5 | 2.3 | 0.02 | |
| Diplotype H2/H2 | 20.1 | 5.3 | 3.8 | 2.2 × 10−4 | |
| Copy no.: 2 | 5.5 | 4.8 | 1.1 | 0.25 | |
| DHT-glucuronide formation (pmol/min per mg of microsomal protein) | Intercept | −8.5 | 11 | −0.8 | 0.44 |
| Male | 15.6 | 6.4 | 2.45 | 0.015 | |
| Adolescence | 27.5 | 14 | 2.0 | <0.05 | |
| Adulthood | 42.8 | 9.9 | 4.3 | 2.7 × 10−5 | |
| Diplotype H3/H4 | 26.5 | 8.7 | 3.1 | 0.003 | |
| Diplotype H2/H2 | 31.5 | 8.4 | 3.8 | 0.0002 | |
| Copy no.: 2 | 2.8 | 7.6 | 0.4 | 0.71 |