Table 4.

Fold change enrichment of human deafness gene homologs in Tg(myo6b:RiboTag) IP samples.

Ensembl ID	Zebrafish gene name	Human homolog	Human disease	Fold enrichment in zebrafish HCs	p-value	FDR	Previously reported expression in zebrafish HCs
ENSDARG00000074638	loxhd1b	LOXHD1	AR non-syndromic deafness	77.35484	3.01E−57	1.6E–53	NA
ENSDARG00000094738	loxhd1a	LOXHD1	AR non-syndromic deafness	47.78006	8.84E−20	1.63E–17	NA
ENSDARG00000056386	tmc1	TMC1	AD and AR non-syndromic deafness	15.46066	0.00102	0.007132	Maeda et al., 2014; Erickson et al., 2017
ENSDARG00000053074	gipc3	GIPC3	AR non-syndromic deafness	15.4136	4.61E−26	1.7E–23	NA
ENSDARG00000105391	si:cabz01059983.1	STRC	AR non-syndromic deafness	14.00558	7.37E−16	7.78E–14	NA
ENSDARG00000056458	lhfpl5b	LHFPL5	AR non-syndromic deafness	12.75537	2.74E−07	5.53E–06	NA
ENSDARG00000020581	otofb	OTOF	AR non-syndromic deafness	12.37504	4.49E−29	2.6E–26	Chatterjee et al., 2015
ENSDARG00000105434	grxcr1	GRXCR1	AR non-syndromic deafness	10.61186	4.21E−07	8.07E–06	NA
ENSDARG00000053692	grxcr2	GRXCR2	AR non-syndromic deafness	10.00353	0.011347	0.052075	NA
ENSDARG00000074742	elmod3	ELMOD3	AR non-syndromic deafness	7.635278	0.043045	0.145634	NA
ENSDARG00000053315	tmprss3a	TMPRSS3	AR non-syndromic deafness	7.302665	2.63E−15	2.52E–13	NA
ENSDARG00000008849	ptprq	PTPRQ	AR non-syndromic deafness	6.882463	0.030491	0.11237	NA
ENSDARG00000008127	pcdh15b	PCDH15	Usher syndrome type 1F and 1D, AR non-syndromic deafness	6.751992	6.03E−09	1.81E–07	Seiler et al., 2005; Maeda et al., 2014
ENSDARG00000076414	espn	ESPN	AR non-syndromic deafness	6.702256	0.00318	0.018583	NA
ENSDARG00000030832	otofa	OTOF	AR non-syndromic deafness	6.1553	6.87E−12	3.71E–10	Thisse and Thisse, 2004; Chatterjee et al., 2015
ENSDARG00000040046	snai2	SNAI2	Waardenburg syndrome	5.542076	1.21E−13	9.15E–12	NA
ENSDARG00000052277	cabp2b	CABP2	AR non-syndromic deafness	5.462416	1.59E−13	1.18E–11	Di Donato et al., 2013
ENSDARG00000045023	lhfpl5a	LHFPL5	AR non-syndromic deafness	5.390774	0.002062	0.012931	Erickson and Nicolson, 2015
ENSDARG00000075870	triobpa	TRIOBP	AR non-syndromic deafness	5.012163	6.12E−13	4.04E–11	NA
ENSDARG00000005335	slc22a4	SLC22A4	AR non-syndromic deafness	4.781316	0.000239	0.002071	NA
ENSDARG00000029482	ush2a	USH2A	Usher syndrome type 2A	4.61055	0.047798	0.157459	Blanco-Sánchez et al., 2014
ENSDARG00000105136	ccdc50	CCDC50	AD non-syndromic deafness	4.590251	9.01E−11	3.98E–09	NA
ENSDARG00000006385	triobpb	TRIOBP	AR non-syndromic deafness	3.836217	5.98E−08	1.44E–06	NA
ENSDARG00000042141	myo6b	MYO6	AD and AR non-syndromic deafness	3.512935	0.007429	0.037159	Seiler et al., 2005; McDermott et al., 2007
ENSDARG00000010192	pax3a	PAX3	Waardenburg syndrome	3.496733	0.038943	0.134993	NA
ENSDARG00000012397	eya4	EYA4	AD non-syndromic deafness	3.495119	0.000225	0.001968	Kozlowski et al., 2005; Wang et al., 2008
ENSDARG00000069423	tmie	TMIE	AR non-syndromic deafness	3.285445	0.00012	0.001138	Shen et al., 2008; Gleason et al., 2009
ENSDARG00000068166	dfnb31b	WHRN	Usher syndrome type 2D, AR non-syndromic deafness	2.864421	0.010032	0.047095	Blanco-Sánchez et al., 2014
ENSDARG00000011407	col2a1b	COL2A1	Stickler syndrome	2.802449	0.002457	0.014951	NA
ENSDARG00000102128	eps8	EPS8	AR non-syndromic deafness	2.782384	0.000132	0.001236	NA
ENSDARG00000010186	myo3a	MYO3A	AR non-syndromic deafness	2.523912	0.011106	0.051163	NA
ENSDARG00000045302	smpx	SMPX	X-linked non-syndromic deafness	2.435658	0.000595	0.004516	NA
ENSDARG00000042707	cx30.3	GJB2	AD keratitis-ichthyosis-deafness syndrome, AD and AR nonsyndromic deafness	2.33159	0.000102	0.000991	Tao et al., 2010; Chang-Chien et al., 2014
ENSDARG00000002831	col4a4	COL4A4	Alport syndrome	2.309518	0.032912	0.119212	NA
ENSDARG00000003395	col4a3	COL4A3	Alport syndrome	2.136137	0.03126	0.114457	NA
ENSDARG00000026165	col11a1a	COL11A1	Stickler syndrome	2.073293	0.025006	0.096541	Thisse and Thisse, 2004; Fang et al., 2010 (otic vesicle)

AR, autosomal recessive; AD, autosomal dominant.