Fig. 4.

MDS-like disease of Setd2 deficiency is reproducible in primary ncBMT mice. a Routine blood test follow-up. Setd2 KO ncBMT mice are divided to two groups: mice in group1 (KO1) did not develop MDS-like disease (n = 6), whereas mice in group2 (KO2) did (n = 4). WT = 10. b Proportion follow-up of donor-derived myeloid cells. WT, n = 10; KO2, n = 4. c Spleen size and morphology analysis. Representative morphology is displayed. n = 3. d Proportion analysis of different mature lineages in total or donor-derived spleen cells. n = 3. e Proportion analysis of EGFP-positive cells in spleen erythroid cells. n = 3. f Absolute cell count of LSK and LK cells in total or donor-derived spleen cells. n = 3. g Proportion analysis of different erythroid subsets in total and donor-derived BM cells. n = 3. h Proportion analysis of donor-derived cells in different spleen cell subsets. n = 3. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001