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. 2018 Feb 22;28(4):416–432. doi: 10.1038/s41422-018-0011-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Ipilimumab does not block human B7-human CTLA-4 interaction in vivo. a FACS profiles depicting composition of human leukocytes among the peripheral blood leukocytes (PBL) of NSG^TM mice reconstituted with human cord blood CD34⁺ cells. b Summary data of individual mice as analyzed in a. c Normal composition of Treg cells and DCs in spleen of humanized NSG^TM mice. d Expression of FOXP3 and CTLA-4 among human CD4 T cells in mice spleen. e, f L3D10 but not Ipilimumab blocks human B7-2-human CTLA-4 interaction in the human cord blood CD34⁺ stem cell-reconstituted NSG™ mice. The humanized mice received intraperioneal treatment of either control Ig or anti-CTLA-4 mAbs (500 μg/mouse). Splenocytes were harvested at 24 h after injection and analyzed for expression of B7 on DC. e Representative profiles of hB7-2 on DC. f Summary data (mean ± S.E.M.) from two independent experiments. The mean data in the control mice are artificially defined as 100 and those in experimental groups are normalized against the control. Statistical significance was determined using Student’s t test. *P < 0.05, **P < 0.01, ***P < 0.001. n.s., not significant