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. 2018 May 1;6:120. doi: 10.3389/fped.2018.00120

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Copyright © 2018 Douglas-Escobar, Mendes, Rossignol, Bliznyuk, Faraji, Ahmad, Doré and Weiss.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cortical and hippocampal volumes. At 12 days of age (5 days post injury), the brain region volumes are represented as the ratio of the left (injured)/right (uninjured). (A) The cortical volumes of HI+A were decreased compared to sham pups (n = 8, ^*p < 0.05). The HI+CO (treated with 1 h per day of 250 ppm of CO for 3 days post injury) had significant preservation of the ratio of ipsilateral to contralateral cortex compared the HI+A group (n = 10, #p < 0.05). (B) The hippocampal volumes of the HI+A (median 0.76, 25% 0.52, 75% 0.84, n = 9) were decreased compared to the sham pups (n = 5, p < 0.05). The HI+CO (treated with 1 h per day of 250 ppm of CO for 3 days post injury) preservation of the ratio of ipsilateral to contralateral hippocampus was not significantly different from the HI+RA group (n = 10).