Fig. 1.

Complexity of drug effectiveness for single-cell intratumor heterogeneity. Phenotypes from targeting a single cell within a tumor with two drugs green + red may result in either (A) disjoint target effects, (B) green targets effects being superset of red targets, (C) red target effects superset of green targets, (D) disjoint and shared effects, (E and F) dominant effects, (G) tumor requiring an additional drug to target all cells with blue effects for maximum effect, or (H) tumor requiring only two drugs instead of three drugs to target all cells.