Table 2.

The discussed growth factors and their effect on neurogenesis

Growth	Stimulates the  ...	Receptor –
Factor	stage of neurogenesis	cellular mechanism
BDNF	Survival	TrkB - CREB, ERK
NT-3	Survival	TrkC
NGF	Survival	TrkA - Akt
CNTF	Proliferation	CNTFR - STAT3
FGF-2	Proliferation	FGF-R - NDY1/EZH2
IGF-1	Proliferation	IGF-1R - MAPK/ERK, Akt
VEGF	Proliferation	Flk-1 - MAPK/ERK, Akt

What we know so far of the effect the mentioned growth factors have on neurogenesis and the mechanisms with which they exert this effect. BDNF = brain derived neurotrophic factor; CNTF = ciliary neurotrophic factor; CNTFR = CNTF-receptor; FGF-2 = fibroblast growth factor 2; Flk-1 = fetal liver kinase–1; IGF-1 = insulin-like growth factor 1; IGF-1R=IGF-1 receptor; NGF = neuronal growth factor; NT-3 = neurotrophin-3; TrkA/B/C = tyrosine kinase receptor A/B/C; VEGF = vascular endothelial growth factor.